I have reviewing and lecturing on the emergency cardiology literature for the past 25 years. During that time, there have been some very important advances in our knowledge and clinical practice based on the published literature, but there have also been some very thought-provoking studies that have not (yet?) been incorporated into our practice. During this lecture, I will discuss some of my favorite and most important, practice-changing emergency cardiology publications that we all should be aware of from the past quarter-century. Some of those articles I discuss will be well-known studies, and others will be critically-important articles that for one reason or another fell through the cracks.