Single Maintenance and Reliever Therapy (SMART) offers an innovative approach to asthma management by combining maintenance and reliever medications in a single inhaler. This session provides a concise review of SMART therapy, including its development, guideline recommendations, and outcomes compared to traditional approaches. Key topics include the MANDALA trial, benefits for patient adherence, impact on exacerbation rates, and cost considerations. We’ll discuss when SMART may be preferred over albuterol at ED discharge, its pros and cons, and practical applications for emergency physicians. Attendees will leave equipped with knowledge to integrate SMART into clinical practice, improving asthma care and patient outcomes in the emergency setting.